Corpus ID: 33047257

Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.

@article{Bracken2006CellspecificRO,
  title={Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.},
  author={C. Bracken and A. Fedele and S. Linke and Wiltiana Balrak and K. Lisy and M. Whitelaw and D. Peet},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 32},
  pages={
          22575-85
        }
}
The hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha are closely related, key transcriptional regulators of the hypoxic response, countering a low oxygen situation with the up-regulation of target genes associated with numerous processes, including vascularization and glycolysis. This involves a dual mechanism of control through both stabilization and transactivation, regulated via prolyl and asparaginyl hydroxylation. Despite high similarity with respect to protein sequence and activation… Expand
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