Cell-specific regulation of alpha1(III) and alpha2(V) collagen by TGF-beta1 in tubulointerstitial cell models.

@article{Bertelli1998CellspecificRO,
  title={Cell-specific regulation of alpha1(III) and alpha2(V) collagen by TGF-beta1 in tubulointerstitial cell models.},
  author={Roberta Bertelli and Fulvia Valenti and Roberta Oleggini and Gianluca Caridi and Paolo Altieri and Domenico Coviello and Gerardo Botti and Roberto Ravazzolo and Gian Marco Ghiggeri},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={1998},
  volume={13 3},
  pages={
          573-9
        }
}
BACKGROUND TGF-beta1 modulates the cellular expression of extracellular matrix (ECM) in several renal cell systems in vitro and is considered a determinant of ECM accumulation in tubulointerstitial fibrosis. METHODS We evaluated the effects of TGF-beta1 on collagen transcription, expression, and removal of the relevant collagens by rat tubuloepithelial cells (NRK 52E) and both rat and monkey interstitial fibroblasts (NRK 49F, CV1) in vitro. RESULTS TGF-beta1 upregulated the expression of… CONTINUE READING
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