Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy

@article{Pierre2000CellspecificLO,
  title={Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy},
  author={K. J. St. Pierre and Luc Pellerin and Ruth Debernardi and B{\'e}at Michel Riederer and Pierre J. Magistretti},
  journal={Neuroscience},
  year={2000},
  volume={100},
  pages={617-627}
}
Recent evidence suggests that lactate could be a preferential energy substrate transferred from astrocytes to neurons. This would imply the presence of specific transporters for lactate on both cell types. We have investigated the immunohistochemical localization of two monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain. Using specific antibodies raised against MCT1 and MCT2, we found strong immunoreactivity for each transporter in glia limitans, ependymocytes and several… CONTINUE READING
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