Cell-specific internalization study of an aptamer from whole cell selection.

  title={Cell-specific internalization study of an aptamer from whole cell selection.},
  author={Zeyu Xiao and Dihua Shangguan and Zehui Cao and Xiaohong Fang and Weihong Tan},
  volume={14 6},
Nucleic acid aptamers have been shown many unique applications as excellent probes in molecular recognition. However, few examples are reported which show that aptamers can be internalized inside living cells for aptamer functional studies and for targeted intracellular delivery. This is mainly due to the limited number of aptamers available for cell-specific recognition, and the lack of research on their extra- and intracellular functions. One of the major difficulties in aptamers' in vivo… CONTINUE READING

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