Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis.

Abstract

Rett syndrome (RTT), a leading cause of mental retardation with autistic features in females, is caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2). RTT is characterized by a diverse set of neurological features that includes cognitive, motor, behavioral and autonomic disturbances. The diverse features suggest that specific… (More)

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@article{AlvarezSaavedra2007CellspecificEO, title={Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis.}, author={Mat{\'i}as Alvarez-Saavedra and Mauricio A S{\'a}ez and Dongcheul Kang and Huda Y. Zoghbi and Juan I. Young}, journal={Human molecular genetics}, year={2007}, volume={16 19}, pages={2315-25} }