Cell-specific expression of aromatase and LH receptor mRNAs in rat ovary.

  title={Cell-specific expression of aromatase and LH receptor mRNAs in rat ovary.},
  author={P F Whitelaw and Clifford Smyth and Colin M. Howles and Stephen G. Hillier},
  journal={Journal of molecular endocrinology},
  volume={9 3},
Current understanding of the endocrine and paracrine regulation of follicular oestrogen synthesis predicts that aromatase cytochrome P450 (P450arom) mRNA is inducible by FSH in granulosa cells. LH receptor mRNA is constitutively expressed in thecal/interstitial cells, and is also thought to be induced in granulosa cells in response to joint stimulation by FSH and oestrogen. This study provides direct evidence that FSH induces the ovarian P450arom gene selectively, perhaps exclusively, in the… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…