Cell-specific expression of a transfected human alpha 1-antitrypsin gene.

@article{Ciliberto1985CellspecificEO,
  title={Cell-specific expression of a transfected human alpha 1-antitrypsin gene.},
  author={G. Ciliberto and L. Dente and R. Cortese},
  journal={Cell},
  year={1985},
  volume={41 2},
  pages={531-40}
}
We have cloned the human alpha 1-antitrypsin (alpha 1-AT) gene and identified the promoter and the transcription initiation point. The cloned gene, following transfection, is expressed in a cell-specific manner, being transcribed in a human hepatoma cell line (Hep3B) but not in HeLa cells. We show that the 5' flanking region of the alpha 1-AT gene contains DNA sequences sufficient for efficient transcription in Hep3B but not in HeLa cells. This DNA sequence also activates, in a cell-specific… CONTINUE READING

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