Cell-specific expression and function of adenylyl cyclases in rat pituitary tumour cell lines.

@article{Paulssen1994CellspecificEA,
  title={Cell-specific expression and function of adenylyl cyclases in rat pituitary tumour cell lines.},
  author={R H Paulssen and Per Wiik Johansen and Jan Oxholm Gordeladze and O Nymoen and E J Paulssen and Kaare M. Gautvik},
  journal={European journal of biochemistry},
  year={1994},
  volume={222 1},
  pages={97-103}
}
The present study demonstrates cell-specific distribution and describes distinct functional regulation of different adenylyl cyclases (AC, types I-VI) in rat pituitary cell tumor cell lines (GH12C1, GH3 and GH4C1 cells) and pituitary tissue. Northern-blot analysis revealed a distinct pattern of cell-specific expression of the different AC types; Ca2+/calmodulin (CaM)-insensitive AC type II was found in all cell lines tested except GH(1)2C1 cells. The Ca(2+)-inhibitable AC type VI was found in… CONTINUE READING