Cell-specific establishment of poliovirus resistance to an inhibitor targeting a cellular protein.

Abstract

UNLABELLED It is hypothesized that targeting stable cellular factors involved in viral replication instead of virus-specific proteins may raise the barrier for development of resistant mutants, which is especially important for highly adaptable small (+)RNA viruses. However, contrary to this assumption, the accumulated evidence shows that these viruses… (More)
DOI: 10.1128/JVI.00055-15

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