Cell-specific and endothelium-dependent regulations of matrix metalloproteinase-2 in rat aorta

Abstract

Chronic activation of angiotensin II (ANGII) and matrix metalloproteinase-2 (MMP-2) during hypertension contributes to increased aortic stiffness. We studied signalling mechanisms employed by ANGII in the regulation of latent (pro-) and active forms of MMP-2 in rat aortic endothelial and smooth muscle cells, along with isolated rat aorta. Using western… (More)
DOI: 10.1007/s00395-014-0419-8

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@article{Kopaliani2014CellspecificAE, title={Cell-specific and endothelium-dependent regulations of matrix metalloproteinase-2 in rat aorta}, author={Irakli Kopaliani and M{\'e}lanie Martin and Birgit Zatschler and Katrin Bortlik and Bianca M{\"{u}ller and Andreas J. Deussen}, journal={Basic Research in Cardiology}, year={2014}, volume={109}, pages={1-16} }