Cell-specific Regulation of Hypoxia-inducible Factor (HIF)-1α and HIF-2α Stabilization and Transactivation in a Graded Oxygen Environment*

@article{Bracken2006CellspecificRO,
  title={Cell-specific Regulation of Hypoxia-inducible Factor (HIF)-1$\alpha$ and HIF-2$\alpha$ Stabilization and Transactivation in a Graded Oxygen Environment*},
  author={C. Bracken and A. Fedele and S. Linke and Wiltiana Balrak and K. Lisy and M. Whitelaw and D. Peet},
  journal={Journal of Biological Chemistry},
  year={2006},
  volume={281},
  pages={22575 - 22585}
}
The hypoxia-inducible factor (HIF)-1α and HIF-2α are closely related, key transcriptional regulators of the hypoxic response, countering a low oxygen situation with the up-regulation of target genes associated with numerous processes, including vascularization and glycolysis. This involves a dual mechanism of control through both stabilization and transactivation, regulated via prolyl and asparaginyl hydroxylation. Despite high similarity with respect to protein sequence and activation pathway… Expand

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References

SHOWING 1-10 OF 21 REFERENCES
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.
...
1
2
3
...