Cell-specific RNA-binding proteins in human disease.

  title={Cell-specific RNA-binding proteins in human disease.},
  author={Kiran Musunuru},
  journal={Trends in cardiovascular medicine},
  volume={13 5},
Cell-specific RNA-binding proteins (RBPs) are involved in a variety of processes that are critical for appropriate protein expression (e.g., alternative splicing of messenger RNAs and translational control). Perturbation of the normal functions of RBPs has been implicated in a number of clinical disorders. Disease-related RBPs include the CELF proteins, which are believed to play roles in normal heart and skeletal muscle development and in the pathology of myotonic dystrophy; the Nova… CONTINUE READING
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