Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity.

@article{Zhou2015CellspecificRA,
  title={Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity.},
  author={J Y Zhou and Sangeetha Satheesan and Haitang Li and Marc S Weinberg and Kevin Morris and John C Jr. Burnett and John J. Rossi},
  journal={Chemistry & biology},
  year={2015},
  volume={22 3},
  pages={
          379-90
        }
}
The C-C chemokine receptor type 5 (CCR5) is a receptor expressed by T cells and macrophages that serves as a coreceptor for macrophage-tropic HIV-1. Loss of CCR5 is associated with resistance to HIV-1. Here, we combine the live-cell-based SELEX with high-throughput sequencing technology to generate CCR5 RNA aptamers capable of specifically targeting HIV-1 susceptible cells (as small interfering RNA [siRNA] delivery agent) and inhibiting HIV-1 infectivity (as antiviral agent) via block of the… CONTINUE READING
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