Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells.

@article{MornSalvador2013CellspecificPD,
  title={Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells.},
  author={Eva Mor{\'a}n-Salvador and Esther Titos and Bibiana Rius and Ana Gonz{\'a}lez-P{\'e}riz and Ver{\'o}nica Garc{\'i}a-Alonso and Cristina L{\'o}pez-Vicario and Rosa Miquel and Yaacov Barak and Vicente Arroyo and Joan Cl{\`a}ria},
  journal={Journal of hepatology},
  year={2013},
  volume={59 5},
  pages={1045-53}
}
BACKGROUND & AIMS PPARγ plays an essential role in the transcriptional regulation of genes involved in lipid and glucose metabolism, insulin sensitivity, and inflammation. We recently demonstrated that PPARγ plays a causative role in hepatocyte lipid deposition, contributing to the pathogenesis of hepatic steatosis. In this study, we investigated the role of PPARγ in the inflammatory and fibrogenic response of the liver. METHODS Heterozygous floxed/null Cre/LoxP mice with targeted deletion of… CONTINUE READING
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