Cell size and Cln-Cdc28 complexes mediate entry into meiosis by modulating cell growth.

@article{Day2004CellSA,
  title={Cell size and Cln-Cdc28 complexes mediate entry into meiosis by modulating cell growth.},
  author={Audra Day and Jody Markwardt and Rolando Delaguila and Jian Zhang and Kedar Purnapatre and Saul M Honigberg and Brandt L. Schneider},
  journal={Cell cycle},
  year={2004},
  volume={3 11},
  pages={1433-9}
}
In the yeast Saccharomyces cerevisiae, mitotic cell cycle progression depends upon the G(1)-phase cyclin-dependent kinase Cln-Cdc28 and cell growth to a minimum cell size. In contrast, Cln-Cdc28 inhibits entry into meiosis, and a cell growth requirement for sporulation has not been established. Here, we report that entry into meiosis also depends upon cell growth. Moreover, sporulation and cell growth rates were proportional to cell size; large cells grew rapidly and sporulated sooner while… CONTINUE READING

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