Cell signalling pathways underlying induced pluripotent stem cell reprogramming.

  title={Cell signalling pathways underlying induced pluripotent stem cell reprogramming.},
  author={Kate E. Hawkins and Shona Joy and Tristan R McKay},
  journal={World journal of stem cells},
  volume={6 5},
Induced pluripotent stem (iPS) cells, somatic cells reprogrammed to the pluripotent state by forced expression of defined factors, represent a uniquely valuable resource for research and regenerative medicine. However, this methodology remains inefficient due to incomplete mechanistic understanding of the reprogramming process. In recent years, various groups have endeavoured to interrogate the cell signalling that governs the reprogramming process, including LIF/STAT3, BMP, PI3K, FGF2, Wnt… CONTINUE READING
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