Cell signalling (communication arising): Cell survival and a Gadd45-factor deficiency

Tumour-necrosis factor-α (TNF-α) is an important protein that regulates inflammation, immunity, cell survival and cell death in response to infection or chronic stress. De Smaele et al. report that the gene encoding an inducible cellular factor, Gadd45β (for 'growth arrest and DNA damage'), is essential for promoting TNF-α-mediated cell survival. However… CONTINUE READING