Cell signaling through membrane mucins.

@article{Carraway2003CellST,
  title={Cell signaling through membrane mucins.},
  author={Kermit L. Iii Carraway and Victoria Palau Ramsauer and Bushra Haq and Coralie A Carothers Carraway},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2003},
  volume={25 1},
  pages={
          66-71
        }
}
MUC1 and MUC4 are the two membrane mucins that have been best characterized. Although they have superficially similar structures and have both been shown to provide steric protection of epithelial surfaces, recent studies have also implicated them in cellular signaling. They act by substantially different mechanisms, MUC4 as a receptor ligand and MUC1 as a docking protein for signaling molecules. MUC4 is a novel intramembrane ligand for the receptor tyrosine kinase ErbB2/HER2/Neu, triggering a… CONTINUE READING
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