Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations.

@article{MiyakawaNaito2003CellSM,
  title={Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations.},
  author={Ayako Miyakawa-Naito and Per Uhl{\'e}n and Mark A Lal and Oleg Aizman and Katsuhiko Mikoshiba and Hjalmar Brismar and Sergey Zelenin and Anita C. Aperia},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 50},
  pages={50355-61}
}
Recent studies indicate novel roles for the ubiquitous ion pump, Na,K-ATPase, in addition to its function as a key regulator of intracellular sodium and potassium concentration. We have previously demonstrated that ouabain, the endogenous ligand of Na,K-ATPase, can trigger intracellular Ca2+ oscillations, a versatile intracellular signal controlling a diverse range of cellular processes. Here we report that Na,K-ATPase and inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R) form a cell… CONTINUE READING

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