Cell signaling in oxidative stress-induced liver injury.

  title={Cell signaling in oxidative stress-induced liver injury.},
  author={Mark J. Czaja},
  journal={Seminars in liver disease},
  volume={27 4},
Oxidative stress is a common mechanism of liver injury. Recent investigations have demonstrated that oxidant-induced liver injury is mediated by the direct effects of reactive oxygen species on signal transduction pathways. Although the function of cell signaling in this form of injury is complex and likely variable depending on the type and duration of oxidative stress, common regulatory pathways of hepatocyte oxidant injury have been identified that include the mitogen-activated protein… CONTINUE READING


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