Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.

@article{Castellv2009CellSI,
  title={Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.},
  author={Josep Castellv{\'i} and Angel Garcia and Carmen Ru{\'i}z-Marcell{\'a}n and Javier Hern{\'a}ndez-Losa and Vicente Peg and Mayte Salcedo and Antonio Gil-Moreno and Santiago Ramon Y Cajal},
  journal={Human pathology},
  year={2009},
  volume={40 10},
  pages={1418-26}
}
In the oncogenic process, cell growth control plays a crucial role, and growth factor receptors and their signaling pathways are known to be altered in endometrial cancer, mostly in type I carcinomas. Two main pathways are involved in transmitting the proliferative signal from the membrane receptors to the nucleus: phosphatydil-inositol-3-kinase-protein… CONTINUE READING