Cell signaling can direct either binary or graded transcriptional responses.

@article{Biggar2001CellSC,
  title={Cell signaling can direct either binary or graded transcriptional responses.},
  author={Stephen R. Biggar and Gerald R Crabtree},
  journal={The EMBO journal},
  year={2001},
  volume={20 12},
  pages={3167-76}
}
Transcriptional control is generally thought to operate as a binary switch, a behavior that might explain observations such as monoallelic gene expression, stochastic phenotypic changes and bimodal gene activation kinetics. By measuring the activity of the single-copy GAL1 promoter in single cells, we found that changes in the activities of either the transcriptional activator, Gal4 (by simple recruitment with synthetic ligands), or the transcriptional repressor, Mig1, generated graded (non… CONTINUE READING