Cell sheet transplantation of cultured mesenchymal stem cells enhances bone formation in a rat nonunion model.

@article{Nakamura2010CellST,
  title={Cell sheet transplantation of cultured mesenchymal stem cells enhances bone formation in a rat nonunion model.},
  author={Akifumi Nakamura and Manabu Akahane and Hideki Shigematsu and Mika Tadokoro and Yusuke Morita and Hajime Ohgushi and Yoshiko Dohi and Tomoaki Imamura and Yasuhito Tanaka},
  journal={Bone},
  year={2010},
  volume={46 2},
  pages={418-24}
}
Orthopedic surgeons have long been troubled by cases involving nonunion of fractured bones. This study aimed to enhance bone union by cell sheet transplantation of mesenchymal stem cells. A nonunion model was made in rat femur, and rat bone marrow cells were cultured in medium containing dexamethasone and ascorbic acid phosphate to create a cell sheet that could be scraped off as a single sheet. Cell sheets were transplanted onto fractured femurs without a scaffold in the model. X-ray and… CONTINUE READING

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