Cell sheet-engineered bones used for the reconstruction of mandibular defects in an animal model.

@article{Du2015CellSB,
  title={Cell sheet-engineered bones used for the reconstruction of mandibular defects in an animal model.},
  author={Chunhua Du and Chao Yao and Ningyi Li and Shuangyi Wang and Yuanyong Feng and Xuecai Yang},
  journal={Experimental and therapeutic medicine},
  year={2015},
  volume={10 6},
  pages={2216-2220}
}
The aim of the present study was to investigate the generation of cell sheet-engineered bones used for the reconstruction of mandibular defects. Bone marrow stem cells (BMSCs) were cultured and induced to generate osteoblasts. Poly(lactic-co-glycolic acid) (PLGA) scaffolds were wrapped with or without cell sheets and then implanted into dogs with mandibular defects in the right side (experimental group) or the left side (control group), respectively. Subsequently, X-ray analyses, and… CONTINUE READING