Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells.

@article{Sapir2005CellreplacementTF,
  title={Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells.},
  author={Tamar Sapir and Keren Shternhall and Irit Meivar-Levy and Tamar Blumenfeld and Hamutal Cohen and Ehud Skutelsky and Smadar Eventov-Friedman and Iris Barshack and Iris Goldberg and Sarah Pri-Chen and Lya Ben-Dor and Sylvie Polak-Charcon and Avraham Karasik and Ilan Shimon and Eytan Mor and Sarah Ferber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 22},
  pages={7964-9}
}
Shortage in tissue availability from cadaver donors and the need for life-long immunosuppression severely restrict the large-scale application of cell-replacement therapy for diabetic patients. This study suggests the potential use of adult human liver as alternate tissue for autologous beta-cell-replacement therapy. By using pancreatic and duodenal homeobox gene 1 (PDX-1) and soluble factors, we induced a comprehensive developmental shift of adult human liver cells into functional insulin… CONTINUE READING

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