Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wing

@article{Kim1995CellRS,
  title={Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wing},
  author={Jaeseob Kim and Kenneth D Irvine and Sean B. Carroll},
  journal={Cell},
  year={1995},
  volume={82},
  pages={795-802}
}
Appendage formation in insects and vertebrates depends upon signals from both the anterior-posterior and dorsal-ventral (DV) axes. In Drosophila, wing formation is organized symmetrically around the DV boundary of the growing wing imaginal disc and requires interactions between dorsal and ventral cells. Compartmentalization of the wing disc, dorsal cell behavior, and the expression of two dorsally expressed putative signaling molecules, fringe (fng) and Serrate (Ser), are regulated by the… CONTINUE READING
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