Cell proliferation in the livers of male mice and rats exposed to the carcinogen P-dichlorobenzene: evidence for thresholds.

@article{Umemura1998CellPI,
  title={Cell proliferation in the livers of male mice and rats exposed to the carcinogen P-dichlorobenzene: evidence for thresholds.},
  author={Takashi Umemura and Kohei Takada and Carla Schulz and Rolf Gebhardt and Yuji Kurokawa and Gary M Williams},
  journal={Drug and chemical toxicology},
  year={1998},
  volume={21 1},
  pages={57-66}
}
In a previous study, p-dichlorobenzene (pDCB), which is associated with tumorigenicity in male rat kidney and livers of mice of both genders, was found to produce acute increases in cell proliferation in those tissues. To determine whether sustained cell proliferation in the liver in susceptible species correlated with reported carcinogenic effects, we examined the effect of pDCB on cell proliferation in the livers and toxicity to the glutamine synthetase-expressing hepatocyte (GS… CONTINUE READING