Cell proliferation in the atherosclerotic plaques of cholesterol-fed rabbits. Part 3. Histological and radioautographic observations on glucocorticoids-treated rabbits.

@article{Cavallero1976CellPI,
  title={Cell proliferation in the atherosclerotic plaques of cholesterol-fed rabbits. Part 3. Histological and radioautographic observations on glucocorticoids-treated rabbits.},
  author={C. Cavallero and Ugo Di Tondo and Pietro Luigi Mingazzini and R. Tim Nicosia and M. N. Pericoli and Paolo Sarti and Luigi Giusto Spagnoli and Sergio Villaschi},
  journal={Atherosclerosis},
  year={1976},
  volume={25 2-3},
  pages={
          145-52
        }
}
Tritiated thymidine radioautography was employed to study the effect of cortisol and other glucocorticoids on cellular proliferation in the aorta and pulmonary artery of rabbits with cholesterol atherosclerosis. Labelled cell counts showed that glucocorticoids, even after one day and at a relatively low dose, decrease sharply the deoxyribonucleic acid synthesis in the intimal plaques. The hormonal influence on [3H]thymidine uptake seems to be a dose-dependent process. The relative potency of… CONTINUE READING