Cell proliferation and apoptosis in stromal corneal dystrophies.

@article{Szentmry2007CellPA,
  title={Cell proliferation and apoptosis in stromal corneal dystrophies.},
  author={N{\'o}ra Szentm{\'a}ry and Lili Tak{\'a}cs and Andr{\'a}s Berta and B{\'e}la Szende and Ildik{\'o} S{\"u}veges and L{\'a}szl{\'o} V. M{\'o}dis},
  journal={Histology and histopathology},
  year={2007},
  volume={22 8},
  pages={
          837-45
        }
}
The aim of our study was to evaluate corneal cell proliferation and apoptosis in cases of granular, macular and lattice dystrophy, and to provide evidence which may help to clarify whether apoptosis is a pathogenic factor in any of these dystrophies. The study group comprised 39 eyes (from 33 patients) which had undergone penetrating keratoplasty (PK) for stromal dystrophies: these comprised 12 eyes (from 9 patients, 55.5% males) with granular dystrophy, 13 eyes (12 patients, 33.3% males) with… 

Figures and Tables from this paper

P21, p27, bax, cathepsin and survivin pathways in macular dystrophy corneas.
TLDR
It is concluded that the down-regulation of p21, p27 and cathepsin in epithelial cells of macular dystrophy corneas may be related to defense mechanisms against apoptotic cell death.
CHST6 mutation screening and endoplasmatic reticulum stress in macular corneal dystrophy
TLDR
Clinical and in vitro results suggest that the CHST6 mutation associated with MCD is associated with apoptosis, and ER stress is probably involved in this apoptosis pathway.
A novel proteotoxic stress associated mechanism for macular corneal dystrophy.
TLDR
A novel regulatory mechanism is proposed that connects the molecular chaperone and proteasomal clearance system in the pathogenesis of macular corneal dystrophy through inhibition of proteasome inhibition in the HCE-2 cells in vitro.

References

SHOWING 1-10 OF 31 REFERENCES
Corneal endothelial cell apoptosis in patients with Fuchs' dystrophy.
TLDR
This study suggests that apoptosis plays an important role in endothelial cell degeneration in Fuchs' dystrophy and suggests that increased endothelial apoptosis by TEM is needed to ascertain this finding.
Recent advances in corneal stromal dystrophies.
TLDR
Clinically, recently described early features of lattice corneal dystrophy (LCD) include discrete ovoid subepithelial opacities, a diffuse central anterior stromal haze, and anteriorStromal dots and filamentary lines; and reactivity with antibodies against microfibrillar protein at the edges of the deposits.
The role of apoptosis in the pathogenesis of Fuchs endothelial dystrophy of the cornea.
TLDR
DNA fragmentation was seen in the epithelium, stroma, and endothelium in 6 of 7 corneas with Fuchs dystrophy, suggesting that excessive apoptosis may be an important mechanism in the pathogenesis of Fuchs Dystrophy.
Keratocyte apoptosis associated with keratoconus.
TLDR
Chronic keratocyte apoptosis associated with ongoing epithelial injury may link risk factors associated with keratoconus such as chronic eye rubbing, contact lens wear, or atopic eye disease.
[Corneal dystrophies in the light of modern molecular genetic research].
TLDR
The detection of the BIGH 3 gene, which is mainly expressed in the corneal epithelium, and its gene product keratoepithelin, have led to the insight that the so-called anterior membrane dystrophies as well as the more common "classical" stromal dyStrophies are caused by different mutations of the above mentioned BIGH3 gene and are thus to be regarded as epithelial in origin.
Morphometric Analysis of Deposits in Granular and Lattice Corneal Dystrophy: Histopathologic Implications for Phototherapeutic Keratectomy
TLDR
According to the histopathologic corneal deposit size and distribution, PTK may be an effective treatment to increase visual acuity in patients with granular dystrophy more than in those with lattice dystrophies, to delay or even avoid penetrating keratoplasty.
The molecular genetics of the corneal dystrophies--current status.
  • G. Klintworth
  • Medicine
    Frontiers in bioscience : a journal and virtual library
  • 2003
TLDR
Genetic studies on inherited diseases affecting the cornea have provided insight into some of these disorders at a basic molecular level and it has become recognized that distinct clinicopathologic phenotypes can result from specific mutations in a particular gene, as well as some different mutations in the same gene.
The Fas-Fas ligand system and other modulators of apoptosis in the cornea.
TLDR
The Fas system (Fas and Fas ligand) modulators and final common pathway mediators of apoptosis are expressed in corneal cells and the Fas-Fas ligand system is expressed in the cornea and could have important functions in normal cornea physiology and in the pathophysiology of cornea disease, including modulation of keratocyte apoptosis after epithelial injury.
...
...