Cell proliferation, carcinogenesis and diverse mechanisms of telomerase regulation

@article{Krupp2000CellPC,
  title={Cell proliferation, carcinogenesis and diverse mechanisms of telomerase regulation},
  author={Guido Krupp and Wolfram Klapper and Reza M. Parwaresch},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2000},
  volume={57},
  pages={464-486}
}
Replication of linear genomes is incomplete and leaves terminal gaps. Solutions to this ‘end replication’ problem can be traced back to the prebiotic RNA world: ‘fossils’ of the presumptive archetypes of telomere structure and of the telomerase enzyme are retained in the terminal structures of some RNA viruses. Telomerase expression in mammals is ubiquitous in embryonic tissues but downregulated in somatic tissues of adults. Exceptions are regenerative tissues and, notably, tumor cells… CONTINUE READING

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