Cell polarity as a regulator of cancer cell behavior plasticity.

  title={Cell polarity as a regulator of cancer cell behavior plasticity.},
  author={Senthil K Muthuswamy and Bin Xue},
  journal={Annual review of cell and developmental biology},
Cell polarization is an evolutionarily conserved process that facilitates asymmetric distribution of organelles and proteins and that is modified dynamically during physiological processes such as cell division, migration, and morphogenesis. The plasticity with which cells change their behavior and phenotype in response to cell intrinsic and extrinsic cues is an essential feature of normal physiology. In disease states such as cancer, cells lose their ability to behave normally in response to… CONTINUE READING

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