Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

@article{Li1998CellpermeantCI,
  title={Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression},
  author={Wen-hong Li and Juan A. Sanchis Llopis and Michael Whitney and Gregor Zlokarnik and Roger Tsien},
  journal={Nature},
  year={1998},
  volume={392},
  pages={936-941}
}
Inositol 1,4,5-trisphosphate (InsP3) releases calcium from intracellular stores and triggers complex waves and oscillations in levels of cytosolic free calcium,. To determine which longer-term responses are controlled by oscillations in InsP3 and cytosolic free calcium, it would be useful to deliver exogenous InsP3, under spatial and temporal control, into populations of unpermeabilized cells. Here we report the 15-step synthesis of a membrane-permeant, caged InsP3 derivative from myo-inositol… CONTINUE READING
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