Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death.

  title={Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death.},
  author={Christophe Bonny and Anne Oberson and St{\'e}phanie Negri and Christelle Sauser and Daniel F Schorderet},
  volume={50 1},
Stress conditions and proinflammatory cytokines activate the c-Jun NH2-terminal kinase (JNK), a member of the stress-activated group of mitogen-activated protein kinases (MAPKs). We recently demonstrated that inhibition of JNK signaling with the use of the islet-brain (IB) 1 and 2 proteins prevented interleukin (IL)-1beta-induced pancreatic beta-cell death. Bioactive cell-permeable peptide inhibitors of JNK were engineered by linking the minimal 20-amino acid inhibitory domains of the IB… CONTINUE READING
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