Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation.

@article{Kadonosono2015CellPP,
  title={Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation.},
  author={Tetsuya Kadonosono and Akihiro Yamano and Toshiki Goto and Takuya Tsubaki and Mizuho Niibori and Takahiro Kuchimaru and Shinae Kizaka-Kondoh},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={201},
  pages={14-21}
}
Cell-penetrating peptides (CPPs), also referred to as protein transduction domains (PTDs), can mediate the cellular uptake of a wide range of macromolecules including peptides, proteins, oligonucleotides, and nanoparticles, and thus have received considerable attention as a promising method for drug delivery in vivo. Here, we report that CPP/PTDs facilitate the extravasation of fused proteins by binding to neuropilin-1 (NRP1), a vascular endothelial growth factor (VEGF) co-receptor expressed on… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS