Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications.

  title={Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications.},
  author={Zhengrong Guo and Huanyan Peng and Jiwen Kang and Dianxing Sun},
  journal={Biomedical reports},
  volume={4 5},
Cell-penetrating peptides (CPPs), also known as protein transduction domains, are a class of diverse peptides with 5-30 amino acids. CPPs are divided into cationic, amphipathic and hydrophobic CPPs. They are able to carry small molecules, plasmid DNA, small interfering RNA, proteins, viruses, imaging agents and other various nanoparticles across the cellular membrane, resulting in internalization of the intact cargos. However, the mechanisms of CPP internalization remain to be elucidated… CONTINUE READING

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