Cell-penetrating peptides, targeting the regulation of store-operated channels, slow decay of the progesterone-induced [Ca2+]i signal in human sperm

@inproceedings{Morris2015CellpenetratingPT,
  title={Cell-penetrating peptides, targeting the regulation of store-operated channels, slow decay of the progesterone-induced [Ca2+]i signal in human sperm},
  author={Jennifer Morris and Sarah Jones and John Howl and Monika Lukanowska and Linda Lefi{\`e}vre and Stephen J. Publicover},
  booktitle={Molecular human reproduction},
  year={2015}
}
Previous work has provided evidence for involvement of store-operated channels (SOCs) in [Ca(2+)]i signalling of human sperm, including a contribution to the transient [Ca(2+)]i elevation that occurs upon activation of CatSper, a sperm-specific cation channel localized to the flagellum, by progesterone. To further investigate the potential involvement of SOCs in the generation of [Ca(2+)]i signals in human sperm, we have used cell-penetrating peptides containing the important basic sequence… CONTINUE READING
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