Cell-penetrating-peptide-mediated siRNA lung delivery.

  title={Cell-penetrating-peptide-mediated siRNA lung delivery.},
  author={Sterghios A Moschos and Andrew Williams and Mark Andrew Lindsay},
  journal={Biochemical Society transactions},
  volume={35 Pt 4},
The therapeutic application of siRNA (short interfering RNA) shows promise as an alternative approach to small-molecule inhibitors for the treatment of human disease. However, the major obstacle to its use has been the difficulty in delivering these large anionic molecules in vivo. A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell-penetrating peptides), Tat-(48-60) (transactivator of transcription) and penetratin, which have been shown… CONTINUE READING