Cell penetrating peptide TAT can kill cancer cells via membrane disruption after attachment of camptothecin.

@article{Song2015CellPP,
  title={Cell penetrating peptide TAT can kill cancer cells via membrane disruption after attachment of camptothecin.},
  author={Jingjing Song and Yun Zhang and Wei Zhang and Jianbo Chen and Xiaoli Yang and Panpan Ma and Bangzhi Zhang and Beijun Liu and Jing-man Ni and Rui Wang},
  journal={Peptides},
  year={2015},
  volume={63},
  pages={143-9}
}
Attachment of traditional anticancer drugs to cell penetrating peptides is an effective strategy to improve their application in cancer treatment. In this study, we designed and synthesized the conjugates TAT-CPT and TAT-2CPT by attaching camptothecin (CPT) to the N-terminus of the cell penetrating peptide TAT. Interestingly, we found that TAT-CPT and especially TAT-2CPT could kill cancer cells via membrane disruption, which is similar to antimicrobial peptides. This might be because that CPT… CONTINUE READING