Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo

Abstract

Peptide nucleic acids (PNAs) form stable and tight complexes with complementary DNA and/or RNA and would be promising antisense reagents if their cellular delivery could be improved. We show that a 21-mer PNA, complementary to the human galanin receptor type 1 mRNA, coupled to the cellular transporter peptides, transportan or pAntennapedia(43–58), is… (More)
DOI: 10.1038/nbt0998-857

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