Cell orientation response to cyclically deformed substrates: experimental validation of a cell model.

@article{Wang1995CellOR,
  title={Cell orientation response to cyclically deformed substrates: experimental validation of a cell model.},
  author={H Wang and W Ip and Raymond E. Boissy and Edward S. Grood},
  journal={Journal of biomechanics},
  year={1995},
  volume={28 12},
  pages={1543-52}
}
We have developed a stochastic model that describes the orientation response of bipolar cells grown on a cyclically deformed substrate. The model was based on the following hypotheses regarding the behavior of individual cells: (a) the mechanical signal responsible for cell reorientation is the peak to peak surface strain along the cell's major axis (p-p axial strain); (b) each cell has an axial strain threshold and the threshold is normally distributed in the cell population; (c) the cell will… CONTINUE READING

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