Cell organization in soft media due to active mechanosensing.

  title={Cell organization in soft media due to active mechanosensing.},
  author={Ilka B. Bischofs and Ulrich S. Schwarz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 16},
Adhering cells actively probe the mechanical properties of their environment and use the resulting information to position and orient themselves. We show that a large body of experimental observations can be consistently explained from one unifying principle, namely that cells strengthen contacts and cytoskeleton in the direction of large effective stiffness. Using linear elasticity theory to model the extracellular environment, we calculate optimal cell organization for several situations of… CONTINUE READING