Cell of origin of glioma: biological and clinical implications

  title={Cell of origin of glioma: biological and clinical implications},
  author={Sheila R. Alcantara Llaguno and Luis F. Parada},
  booktitle={British Journal of Cancer},
The cellular origin of gliomas remains a topic of controversy in cancer research. Advances in neurobiology, molecular genetics, and functional genomics have ushered new insights through exploiting the development of more sophisticated tools to address this question. Diverse distinct cell populations in the adult brain have been reported to give rise to gliomas, although how these studies relate physiologically to mechanisms of spontaneous tumour formation via accumulation of tumour-initiating… CONTINUE READING
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