General solutions of poroelastic equations with viscous stress
This work adopts a two-phase model that extends Biot theory by including the fluid viscous stresses in the fluid’s momentum equation and uses generalized linear viscoelastic (VE) constitutive equations to describe the permeating fluid and the network stresses and assumes a constant friction coefficient that couples the fluid and network displacement fields.
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- BiologyBiophysical journal
Numerical Simulation of Real-Time Deformability Cytometry To Extract Cell Mechanical Properties.
- Biology, EngineeringACS biomaterials science & engineering
A full numerical model for single cells in a flow channel to quantitatively relate cell deformation to mechanical parameters is proposed and a new measure for Cell Stiffness is introduced that is capable to distinguish between deformation effects stemming from cell cortex and cell bulk elasticity.
Extracting Cell Stiffness from Real-Time Deformability Cytometry: Theory and Experiment
- Biology, EngineeringBiophysical journal
Nuclear Mechanics and Mechanotransduction in Health and Disease
- BiologyCurrent Biology
Atomic force microscopy-based mechanobiology
- Biology, Materials ScienceNature Reviews Physics
The potential of combining AFM with complementary techniques, including optical microscopy and spectroscopy of mechanosensitive fluorescent constructs, super-resolution microscopy, the patch clamp technique and the use of microstructured and fluidic devices to characterize the 3D distribution of mechanical responses within biological systems are outlined.
A unified rheological model for cells and cellularised materials
A novel model combining conventional viscoelastic elements with fractional calculus that successfully captures the macroscopic relaxation response of epithelial monolayers is presented, providing a novel and robust mathematical approach for diagnostic methods based on mechanical traits as well as more accurate computational models of tissues mechanics.
Cell mechanics: dissecting the physical responses of cells to force.
- BiologyAnnual review of biomedical engineering
The stage is now set for the development of detailed models for cell deformability, motility, and mechanosensing that are rooted at the molecular level.
Particle-tracking microrheology of living cells: principles and applications.
- Biology, EngineeringAnnual review of biophysics
The basic principles of particle-tracking microrheology are established, describing the advantages of this approach over more conventional approaches to cell mechanics, and basic concepts of molecular mechanics and polymer physics relevant to themicrorheological response of cells are presented.
The nucleus as a central structure in defining the mechanical properties of stem cells
- Biology2010 Annual International Conference of the IEEE Engineering in Medicine and Biology
Mechanisms of bone marrow CD34+ hematopoietic stem cells (CD34+ cells) and bone marrow stromal cells (BMSCs) is investigated through micropipette aspiration to address the role of the nucleus as a central mechanoactive structure in stem cells.