Cell-nonautonomous function of the retinoblastoma tumour suppressor protein: new interpretations of old phenotypes.

@article{Whyatt2002CellnonautonomousFO,
  title={Cell-nonautonomous function of the retinoblastoma tumour suppressor protein: new interpretations of old phenotypes.},
  author={David Whyatt and Frank Grosveld},
  journal={EMBO reports},
  year={2002},
  volume={3 2},
  pages={130-5}
}
Loss of the retinoblastoma protein (pRb) induces a cell-nonautonomous defect in both erythroid and neuronal differentiation. It has previously been thought that this reflects a requirement for pRb function in cells that normally support erythropoiesis and neurogenesis, rather than in the erythrocytes or neurons themselves. However, recent studies have challenged this interpretation, and it appears that erythrocytes and neurons themselves have the intrinsic requirement for pRb function. This… CONTINUE READING