Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene.

@article{Ghigna2005CellMI,
  title={Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene.},
  author={Claudia Ghigna and Silvia Giordano and Haihong Shen and Federica Benvenuto and Fabio Castiglioni and Paolo Maria Comoglio and Michael R. Green and Silvano Riva and Giuseppe Biamonti},
  journal={Molecular cell},
  year={2005},
  volume={20 6},
  pages={881-90}
}
Ron, the tyrosine kinase receptor for the Macrophage-stimulating protein, is involved in cell dissociation, motility, and matrix invasion. DeltaRon, a constitutively active isoform that confers increased motility to expressing cells, is generated through the skipping of exon 11. We show that abnormal accumulation of DeltaRon mRNA occurs in breast and colon tumors. Skipping of exon 11 is controlled by a silencer and an enhancer of splicing located in the constitutive exon 12. The strength of the… CONTINUE READING