Cell migration-the role of integrin glycosylation.

  title={Cell migration-the role of integrin glycosylation.},
  author={Marcelina Elżbieta Janik and Anna Lityńska and Pierre Vereecken},
  journal={Biochimica et biophysica acta},
  volume={1800 6},
BACKGROUND Cell migration is an essential process in organ homeostasis, in inflammation, and also in metastasis, the main cause of death from cancer. The extracellular matrix (ECM) serves as the molecular scaffold for cell adhesion and migration; in the first phase of migration, adhesion of cells to the ECM is critical. Engagement of integrin receptors with ECM ligands gives rise to the formation of complex multiprotein structures which link the ECM to the cytoplasmic actin skeleton. Both ECM… CONTINUE READING

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