Cell migration/invasion assays and their application in cancer drug discovery.

@article{Eccles2005CellMA,
  title={Cell migration/invasion assays and their application in cancer drug discovery.},
  author={Suzanne A. Eccles and Carol Box and William J. Court},
  journal={Biotechnology annual review},
  year={2005},
  volume={11},
  pages={391-421}
}
Invasive capacity is the single most important trait that distinguishes benign from malignant lesions. Tumour cells, during intravasation and extravasation of blood and lymphatic channels and when establishing colonies at secondary sites, must move through tissue boundaries that normal adult cells (other than, for example activated leukocytes) do not cross. Similar mechanisms are also utilised by activated endothelial cells during the generation of new blood vessels that enable the sustained… CONTINUE READING

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