Cell-microsphere constructs formed with human adipose-derived stem cells and gelatin microspheres promotes stemness, differentiation, and controlled pro-angiogenic potential.

@article{Kodali2014CellmicrosphereCF,
  title={Cell-microsphere constructs formed with human adipose-derived stem cells and gelatin microspheres promotes stemness, differentiation, and controlled pro-angiogenic potential.},
  author={Anjaneyulu Kodali and Thiam Chye Lim and David Tai Leong and Yen Wah Tong},
  journal={Macromolecular bioscience},
  year={2014},
  volume={14 10},
  pages={1458-68}
}
Translation of stem cell therapies to clinical stage requires viable delivery vehicles that can control stem cell behavior. In this study, the suitability of gelatin microspheres (GMs) as such a tissue engineering platform for human adipose derived stem cells (ADSCs) is investigated. ADSCs on GMs, show a significant upregulation of well known pluripotent marker genes, together with the ability to differentiate into multiple cell lineages of adipocytes, osteocytes, and hepatocytes. In addition… CONTINUE READING

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