Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo.


The time course of the beneficial pharmacological effect of a drug has long been considered to depend merely on the temporal fluctuation of its free concentration. Only in the last decade has it become widely accepted that target-binding kinetics can also affect in vivo pharmacological activity. Although current reviews still essentially focus on genuine… (More)
DOI: 10.1111/bcp.12996