Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells.

@article{Kischel2008CellMP,
  title={Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells.},
  author={Philippe Kischel and François Guillonneau and Bruno Dumont and Akeila Bellahc{\'e}ne and Verena Stresing and Philippe Cl{\'e}zardin and Edwin De Pauw and Vincent Castronovo},
  journal={Neoplasia},
  year={2008},
  volume={10 9},
  pages={1014-20}
}
Metastatic breast cancer cells are characterized by their high propensity to colonize the skeleton and form bone metastases, causing major morbidity and mortality. Identifying key proteins involved in the osteotropic phenotype would represent a major step toward the development of both new prognostic markers and new effective therapies. Cell surface proteins differentially expressed in cancer cells are preferred potential targets for antibody-based targeted therapies. In this study, using cell… CONTINUE READING

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